Nov. 16, 2023 – A brand new toothpaste is displaying promise as a remedy to assist adults who’re allergic to peanuts tolerate growing quantities of peanut protein.

The investigational toothpaste is labeled INT301 and it met its security targets in an early randomized, placebo-controlled trial.

Thirty-two adults, ages 18-55, who have been allergic to peanuts, have been enrolled within the 4-month trial. The members have been randomly positioned into teams that obtained both growing quantities of the peanut protein within the toothpaste to check how a lot they may tolerate safely or a placebo toothpaste that had no peanut proteins. The toothpaste was squeezed from a metered dispenser to manage the quantity. 

Neither the particular person giving the members the toothpaste, nor the affected person knew which form of toothpaste they obtained, to assist remove potential bias. 

“INT301 demonstrated security throughout all remedy teams,” stated the examine’s lead creator, William Berger, MD, an allergist and marketing consultant for Intrommune, a biotechnology firm based mostly in New York Metropolis, which developed the toothpaste.

The toothpaste is a type of oral immunotherapy and it exposes the physique to an allergen in tiny however growing quantities over time to construct tolerance in case an individual is by accident uncovered to peanuts. In contrast to another oral immunotherapies, this one targets cells not slightly below the tongue, however in lots of elements of the mouth with the best potential for allergy desensitization, Berger stated.

Berger offered the findings of the OMEGA (Oral Mucosal Escalation Purpose Evaluation) trial Nov. 11 on the American School of Allergy, Bronchial asthma and Immunology Annual Assembly in Anaheim, CA.

All Tolerated the Highest Dose

All members within the remedy arm persistently tolerated the very best dose. As well as, there have been no average or extreme unwanted side effects, Berger stated.

The primary response for many who obtained the remedy toothpaste was delicate itching contained in the mouth that might be eradicated with antihistamines.

Trial regulators had requested the investigators to look at for any dental unwanted side effects and Berger stated the toothpaste didn’t trigger well being within the tooth or mouth.

Early Indicators it’s Efficient

This early examine was primarily a security trial, however the investigators additionally discovered indicators with blood checks that the toothpaste works to assist desensitize adults to peanut protein. Effectiveness will probably be explored additional in a future trial.

Kristin Sokol, MD, MPH, an allergist/immunologist with Schreiber Allergy in Rockville, MD, stated, “As of now, the one choices we’ve got for meals allergy remedy and administration are to inform our sufferers to fully keep away from a meals and carry epinephrine for his or her whole lives,” one other oral immunotherapy. 

Oral immunotherapy is time consuming, and there are substantial logistic concerns. This toothpaste presents a neater choice that households can match into their each day schedules, she stated.

“I am all the time searching for choices like that,” Sokol stated. “Clearly there are extra research that have to be completed. I actually like the security information on this. The zero incidence of anaphylaxis is absolutely vital.”

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