Sort 2 diabetes is without doubt one of the commonest and well-studied trendy ailments. So, new drugs to fight this situation are continually being developed.

One such kind of remedy is known as a glucagon-like peptide 1 (GLP-1) agonist. These meds have grow to be more and more common not too long ago as a result of regardless that GLP-1 receptor agonists have been initially developed to deal with kind 2 diabetes, they started to indicate a really promising profit: vital weight reduction

In the event you suppose you’re a candidate for certainly one of these medicines, learn on to be taught all the pieces it is advisable to learn about GLP-1 agonists for weight reduction, how they work, who ought to take them, their uncomfortable side effects, and extra.

What Are GLP-1 Agonists? 

Hormones are your physique’s pure messengers. They carry necessary messages to completely different organs to maintain your physique functioning usually. Each insulin and GLP-1 peptide are naturally occurring hormones. 

The meals you eat will get damaged down into easy sugars (like glucose) in your abdomen.

This sugar then enters the bloodstream and travels all through the physique. Insulin directs the sugar out of your blood into your cells for use as vitality. 

However when insulin can’t do its job nicely anymore, the sugar stays within the blood, and also you develop kind 2 diabetes.

For this reason individuals with diabetes have higher-than-normal blood sugar ranges. It’s additionally why most diabetes drugs (together with GLP-1 agonists) are focused in direction of blood sugar management. 

However like all good planners, your physique at all times has a backup. When insulin begins slacking off (prefer it does in people with diabetes), your physique sends out the GLP-1 hormone to select up the slack.

When scientists found this sensible transfer, they got here up with a technique to mimic the physique’s actions. Thus, GLP-1 agonists have been developed. 

An agonist is any manufactured substance (like a drug or remedy) that copies or boosts the actions of a naturally occurring substance (on this case, GLP-1) by stimulating its receptor.

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How Does GLP-1 Work? 

GLP-1 is often produced within the small gut. It has a four-fold messenger motion:

  1. It tells the pancreas to extend insulin secretion to handle your blood sugar ranges correctly.
  2. It additionally tells the pancreas to not launch hormones like glucagon, which may transfer glucose from different storage locations (just like the liver) into the bloodstream.
  3. It tells your abdomen to digest the meals slowly in order that extra sugars don’t get added to the bloodstream earlier than insulin can clear them out.
  4. It tells your mind that you simply’re full and never hungry in any respect — aka, it decreases starvation and will increase satiety. This prevents overeating and retains you from taking in additional meals earlier than the earlier meal is absolutely digested. 

This last motion has caught the attention of most of the people and has pushed GLP-1 agonists—essentially the most well-known being semaglutide—into the limelight, even amongst individuals with out diabetes.

GLP-1 agonists can lower your urge for food and maintain you feeling full on a regular basis. They might assist you shed extra pounds, particularly when you discover portion management difficult.

Does this imply anybody can take GLP-1 medication to shed extra pounds? Let’s discover the professionals and cons of taking these drugs for weight reduction results. 

6 Key Issues of GLP-1 Medication 

GLP-1 agonists have been first authorized to be used as kind 2 diabetes remedy by the U.S. Meals and Drug Administration (FDA) in 2005. These medication are often out there in a liquid kind, together with a needle and syringe. 

You want to inject them into the fatty tissue below your pores and skin. The most typical injection website is the stomach, adopted by the outer thighs, higher buttocks, and the backs of your arms.

These medication are often beneficial solely after safer and extra typical strategies like weight loss program and train have failed to provide the specified outcomes.

Even then, GLP-1 agonists aren’t miracle medication and might’t work alone. They have to be accompanied by dietary and way of life adjustments for long-term use.

1. Study who can and can’t take these medication

To learn from GLP-1 agonist medication, your physique mass index ought to both be 30 or larger or be 27 or larger with a well being complication like: 

  • Prediabetes or kind 2 diabetes 
  • Heart problems 
  • Hypertension
  • Excessive ldl cholesterol 
  • Non-alcoholic fatty liver illness
  • Obstructive sleep apnea
  • Polycystic ovarian syndrome

Based on MyFitnessPal’s registered dietician, Stephanie Nelson, you will need to seek the advice of your well being care supplier earlier than beginning this remedy. It’s because taking any remedy comes with sure dangers and doable uncomfortable side effects. A great well being care supplier will assist you weigh the dangers you face by taking the remedy versus the dangers of not taking it.

They’ll additionally issue within the well being advantages you’ll obtain by taking the remedy. These medication are greatest suited to people who’re at well being threat associated to their weight. For instance, you probably have weight problems, you’re at a larger threat of growing diabetes or coronary heart illness. 

However when you’re NOT at well being threat, then these medication aren’t beneficial for you as a result of they put you at pointless threat of uncomfortable side effects.

You additionally shouldn’t take GLP-1s if:

  • You’ve got a private or household historical past of thyroid most cancers, as they enhance the chance of thyroid most cancers.
  • You’re pregnant, breastfeeding, or planning to get pregnant.
  • You’ve got extreme bowel illness.
  • You’re allergic/delicate to semaglutide.
  • You’ve got a previous or lively consuming dysfunction.

One other factor to think about when choosing GLP-1s is the affect of those medication in your meals consumption.  

For instance, GLP-1s impression meals consumption by quieting meals noise and subconsciously getting you to decide on much less salty, sugary, and fatty meals. This speaks to how highly effective your unconscious cues to eat are and the position your mind performs in weight problems. 

However this can be a double-edged sword since you nonetheless should be aware and aware of what you’re consuming to make sure you’re consuming sufficient—which is the place monitoring what you eat is available in.

Whereas taking GLP-1 drugs, it is advisable to keep disciplined about making nutritious meals decisions and monitoring your energy to stop malnutrition and obtain wholesome weight reduction.

Some of the Best Foods While On Semaglutide, According to an Expert | MyFitnessPal

2. Know the GLP-1 medication out there and their effectiveness

Many GLP-1 drugs can be found on the U.S. market. Nonetheless, solely the next three are presently authorized by the FDA to be used as weight-loss medication: 

Semaglutide (Wegovy)

  • Sort: injectable
  • Frequency: weekly 
  • Beginning dose: 0.25 to 1.7 mg for the primary 16 weeks 
  • Upkeep dose: 2.4 mg
  • Efficacy findings:
    1. Producer-sponsored research of 803 and 1,961 individuals: common lower in physique weight of seven.9% and 14.9%, respectively, with smaller waists and decrease whole levels of cholesterol, systolic blood strain, and triglycerides
    2. Analysis evaluation in 2021: weekly dose of Wegovy led to weight discount results in a number of research

Liraglutide (Saxenda)

Tirzepatide (Zepbound)

  • Twin GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist
  • Sort: injectable
  • Frequency: weekly 
  • Beginning dose: 2.5 mg in 0.5-mL liquid answer for the primary 4 weeks 
  • Upkeep dose: 5, 7.5, 10, 12.5, or 15 mg from week 5 (based mostly on therapy response and drug tolerance) 
  • Efficacy findings:
    1. Manufactured-sponsored SURMOUNT-3 trial: whole imply weight lack of 26.6% over 84 weeks
    2. Manufactured-sponsored SURMOUNT-4 trial: whole imply weight lack of 26% over 88 weeks

3. Take note their potential uncomfortable side effects

GLP-1 agonists include an extended checklist of potential adversarial results similar to:

  1. Digestive system: abdomen ache, nausea, vomiting, constipation, diarrhea, heartburn, indigestion, flatulence, bloating, belching, and gastroesophageal reflux
  2. Nervous system: headache, dizziness, fatigue, temper adjustments, and suicidal conduct or ideation
  3. Low blood sugar and diabetic retinopathy in individuals with diabetes
  4. Allergic reactions
  5. Drug interactions
  6. Coronary heart charge adjustments
  7. Gall stones
  8. Pancreatitis 
  9. Kidney harm
  10. Elevated threat of thyroid most cancers

Based on heart specialist and MyFitnessPal scientific advisor Danielle Belardo, MD, most gut-related uncomfortable side effects may be resolved via dietary adjustments like consuming smaller meals, rising fiber consumption, and staying hydrated.

Enjoyable Reality: MyFitnessPal affords a FREE 7-day GLP-1 Vitamin Plan, made in collaboration with consultants from our scientific advisory board. Study extra!

4. Perceive the insurance coverage protection of those medication

Insurance coverage protection for GLP-1 agonists like semaglutide relies on a number of components, similar to the kind of remedy, plan, supplier, and well being situation.

GLP-1s are generally coated by insurance coverage, however provided that deemed medically crucial. For instance, some suppliers cowl them in the event that they’re used to deal with kind 2 diabetes.

Medicare doesn’t cowl these medication for weight reduction, however in some states, Medicaid does.

Be sure you test along with your supplier earlier than beginning this drug. Some plans could require prior authorization or a documented analysis. You may additionally want to satisfy sure well being standards or pay some copayment quantity.

Wegovy and Saxenda price $1,349.02 per month-to-month package deal.

Zepbound prices round $1,059.87 per thirty days.

Novo Nordisk and Eli Lilly (the producers) supply financial savings applications for individuals with out insurance coverage protection.

With this, it can save you round $500 a month for a four-week provide of Wegovy or Zepbound. Based on the corporate, most individuals with industrial protection for this drug pay lower than $25 per thirty days.

5. Know the weight problems therapy options to GLP-1

Listed below are some methods for weight administration if GLP-1s aren’t for you:

  • Go for home-cooked as a substitute of ultra-processed meals.
  • Make small, sustainable adjustments to vitamin.
  • Add extra protein and fiber to your weight loss program.
  • Minimize down on high-sugar drinks. Drink extra plain water as a substitute.
  • Make certain to get sufficient, high-quality sleep.
  • Transfer your physique extra — whether or not it’s via train, taking a stroll, and even doing chores.
  • In excessive circumstances, contemplate different weight reduction therapies like surgical procedure or drugs that trigger weight reduction (like phentermine).
  • Search recommendation from professionals like a registered dietician, psychologist, endocrinologist, or bodily therapist to obtain personalized care tailor-made to your wants.

6. Take note the utmost therapy period for GLP-1

Analysis reveals that individuals acquire round two-thirds of their misplaced weight again inside a yr after stopping GLP-1 dietary supplements. So, these medication might not be your best option for long-term weight reduction. 

Weight problems is taken into account a continual situation. Medication like GLP-1s suppress cravings, enhance insulin sensitivity, and mute obesity-promoting pathways within the physique. However these results may be reversed as soon as the drug is stopped. 

In brief, GLP-1s can be utilized for the therapy of weight problems however can not treatment it utterly. That’s why it is advisable to be mentally ready to be on GLP-1s probably for all times when you want to obtain everlasting advantages.

The Backside Line: GLP-1s Aren’t Proper for Everybody 

Selecting the best drug relies on many components like your well being standing, drug tolerance, funds, and insurance coverage protection. Converse to your well being care supplier earlier than beginning any drugs. 

On the finish of the day, weight loss program and train are simply as necessary in a profitable weight reduction journey. For a straightforward begin, introduce small adjustments like planning your meals, monitoring your energy, or creating an train routine.



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